Postoperative adjuvant therapy

نویسندگان

  • J. L. Van Laethem
  • K. Haustermans
  • P. Hammel
  • J. Closset
  • J. F. Gigot
  • C. Penna
  • B. Nordlinger
  • P. Van Houtte
  • E. Van Cutsem
  • V. Budach
چکیده

Pancreatic cancer is one of the most lethal cancers and has a global survival rate of less than 5% at 5 years. Surgical resection remains the only curative measure but provides a median survival of only 12-15 months, due to the very high rates of both local recurrence and distant metastases1-3. On the basis of this natural history, multiple adjuvant and more recently neoadjuvant therapies have been investigated in order to improve survival. This review is a critical assessment of the results and limitations of such trials and the authors discuss a rationale for the introduction of new developments in the (neo)adjuvant setting of pancreatic cancer.

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تاریخ انتشار 2004